I ran this up to compare loads for the 300 Ninja engines I'm big boring.
https://www.dropbox.com/s/xfm3qns1da...Loads.JPG?dl=0
Rev & weight increase the load much more than combustion. And most engine have 10-20% over engineering for failure free longevity. By this I mean they design/test it to find practical limits then add material &/or strength to components to ensure they don't fail at the prak expected loads. If you don't go too crazy you can use some of that spare capacity & still have a reliable engine.
Note that I am disappointed i the weight of the Wiseco pistons & should have just gone with ZZR600 ones.