If we choose an asymmetric setup, e.g. turbo rotated by 45° right, cooler rotated by 45° left and 60° upwards (i.e. front view approximately like this but with the in/outlet facing backward):
then we have fewer front wheel clearance issues and a much larger angle before the cooler grinds the ground. Weight (~10lbs each) and drag (the air-intake would be on the right) should be distributed fairly evenly. As far as I can tell, the main drawback is that constructing an equal length exhaust manifold will be more difficult and require significantly more piping (i.e. we cannot simply connect the turbo with two mirror-symmetric 1" pipes).