Freeway and hours equal dangerous boredom, perhaps a route that is more interesting?
I would take route 42 South (or 71... yuck) then go across on Route 40 the old "National road", screw 71/75 too many trucks and construction! It'll take you longer but you see some old school Americana and be less fatigued. Route 40 is the Mid-West "Route 66" a nice old, usually empty road. Avoid Columbus.
FYI: take I75W for a few miles to avoid going through Springfield...
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