That's about 10-lbs in weight-savings at outer-edges going with lighter tyres and lighter-weight wheels like the v-Rossis. There's some Marchesinis that are even lighter, but costs 15x more.
I went with 428 due to unpredictable reliability issues with 415. That's nice in-middle solution between 415 vs. 520:
415ER = 1.92-lbs
428NZ = 2.99-lbs
425VM = 3.66-lbs (X-ring)
520V = 3.56-lbs
Nice thing about smaller pitch is you can get finer control on gearing-ratios. I use 18x59t or 18x58t which lets me redline just at end of longest straights at Buttonwillow or Thunderhill. Both those gears are "in-between" 520 14x45t (too tall) and 14x46t (too short).
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