You old people and your worry about turbos on stock vehicles.
They're no better or worse than industry standard across other modern vehicles with or without turbochargers. And just like any other engine on the market right now, if you start messing with engine management via an aftermarket ECU or piggyback ECU, those odds of failure do go up. That's why modifying your car voids the warranty for the parts you touch and/or impact. Just saying... Keep it stock, follow the maintenance plan, use the vehicle within the defined usage (don't pull 20,000 lbs with an F150, duh!), and anything you buy should last you a good long time. If you modify or abuse your vehicle beyond what it was intended to be used for, understand that you're more likely to see issues. That's how it works.
That 3.5L is a beast of an engine and it pairs well with the high gear count tranny's because of its flat torque curve which gives flexibility for programming shifts and power delivery. I'm not normally a Ford fanboyyyyyy (Found On Road Dead, much?
) but I do like the 3.5L EB setup they have right now.