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Saddle with nose up is normal if you want to compensate for shorter distance between saddle and b/b as you more forward on the seat. Having saddle levelled seems more cosmetic unless you are pushing forward with your pedalstrokes. Since majority of forward power generation is on the downstroke, saddle nose up is just keeping the pedaling distance more consistent as you shift atop your saddle forward and back to find different positions when you ride.
Having slightly different seating positions within your saddle can make longer distance rides much more tolerable.
When it comes to gearing, more has good with the terrain within your local riding area and traffic pattern. If the terrain and traffic allows you to spin a 52t chainring without much difficulty and concern over safety, sure.
Personally, spinning a 52t chainring is rarely the reason I ride my bicycle, effort to keep alive without incident at high speed is that much more on a bicycle vs moto or auto. Enjoy the ride, scenery and company of the ride is more important.
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