I've heard that a 16 has problems at least sometimes, but I don't know the specifics, sorry. I'm running 15-42 at the moment, which is about the same as 16-45, and that works fine of course. I'm not sure I like it better than 15-45. I'm still deciding. 15-42 makes 5th gear about where stock 6th was, so it's sort of like a 7th gear, but I downshift more often of course, and acceleration off the line is noticeably less snappy.
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