Gearing shouldn't change MPG because air-resistance is still same at same speed. Thus power-required to move bike at that speed will still be same. With taller-gearing and lower-RPMs, you have to open throttle a little more to generate same power for same speed.
True that you're closer to max-VE of engine at lower-RPMs and have lower pumping-losses with larger throttle-opening. But difference isn't that significant.
I'm using a 16x45t on my newgen and that lowered cruising RPM by about 1000 and makes for a more relaxed ride.
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