I think Spies will do very well this year, now that he's with the factory team. Stoner has been amazing every time he's ridden for his new team. I like Hayden, but he hasn't been a strong finisher with Ducati. However, the "new" bike should help. Lorenzo will do well, he was almost unstoppable last year.
It will be very interesting to see the first races and find out who can really do what. There are a few riders who do not put all of their cards on the table in the practice rounds. No point in showing everyone what to expect before they have to.