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I often run a 120 front on my 250. Why? Because I swap between a r6 and a 250 a lot. So I try to run the same tire profile on both bikes for feel.
Have I noticed any "real" negatives? Naw, not really. I WILL say though, the differences between 110 vs. 120 are as follows; (take these with a grain of salt as your feel may differ from mine and realize, my rear is not the stock height)
Feel on a 120:
No rubbing on stock fender (normal sizes and profiles)
The feel under super hard braking is incredible (tire brand dependant)
More planted feel in corners
Takes a slightly harder countersteer to get the same flickability, but I don't think I lost any performance in this area
Can run others take offs
When the rear tire comes off the ground, it feels more stable (tire brand/profile dependant)
Overall, a 120 will not make that big of a difference to a street rider at sane paces. They are my street tire size of choice.
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