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Emu I didn't pick up on your username, now i gotcha ID'd.
The need for any tuning/jetting is first predicated on judging performance with truly clean, functioning carbs. Undeniable history....folks have justified misguided, experimental jetting changes, compensating for running issues due to carb setup. Hogging out pilot jets, (while other areas of the circuit remain clogged) a prime example. Extreme adjustments, way oversized mains, realities I've encountered.
If you are racing, trying to squeeze every bit out? Have at it.
As I'm not dicing with Valentino Rossi stoplight to stoplight on Main Street, USA, a serviced, maintained, unmolested factory setup more than suffices.